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KMID : 1134820150440091256
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Journal of the Korean Society of Food Science and Nutrition
2015 Volume.44 No. 9 p.1256 ~ p.1263
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Citrus Ethanol Extracts Promotes Innate Immune Response by Activating NF-κB
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Yang Ji-Won
Jeon Hye-Lin
You Yang-Hee
Kim Jin-Young
Choi Hyo-Kyoung
Choi Kyung-Chul
Jun Woo-Jin
Yoon Ho-Geun
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Abstract
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Citrus junos Sieb. ex Tanaka has been traditionally called Yuza in Korea and is used as a cuisine material or tea as well as medicinal herb. In this study, we evaluated the immune-enhancing effect of Citrus junos ethanol extract (CJE) on RAW264.7 mouse macrophage and primary immunocytes. CJE treatment showed increased macrophage activity in a dose-dependant manner. CJE also enhanced natural killer (NK) cell activity. We measured lactate dehydrogenase (LDH) level as a measurement of NK cell cytotoxicity against YAC-1 lymphoma cells. CJE treatment showed an increased LDH level in a dose-dependent manner. Finally, we evaluated the effect of CJE on mouse primary splenocyte proliferation. CJE treatment slightly increased splenocyte proliferation compared to the control. The results of this study suggest that CJE can help immune function via macrophage cytokine production, increased NK cell activity, and splenocyte proliferation.
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KEYWORD
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Citrus junos Sieb. ex Tanaka, immuno-stimulating activity, cytokine, NK cell, RAW264.7 cell
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